Arturo Ferreira ,
نویسندگان
چکیده
The S region of the H-2 complex controls the serum levels of two proteins, Ss and Sip, which are closely related antigenically (1-4). Several observations suggest that the Ss protein may be part of the complement system and homologous to C4. F(ab')2 fragments of antibody to Ss inhibit the hemolytic activity of mouse serum (5) and Ss antigenic determinants are incorporated into immune complexes after complement activation (6). Furthermore, Ss shares some physicochemical properties with C4 of other species (7, 8) and some antisera to human C4 cross-react with Ss (9). As for the Sip protein, its function is unknown. The present report demonstrates that Ss and Sip can be distinguished functionally by (a) their role in the hemolytic complement system, (b) their susceptibility to Cls enzymatic activity, and (c) their affinity for the C4-binding protein (C4-bp) 1 (10, 11). In addition, new information regarding structural characteristics of these two proteins is presented.
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